It's a comic about the adventures of a group of (huge surprise) goblins. It's quite funny (and at times gory), and it's very closely based on Dungeons & Dragons, more so than Looking For Group, constantly referencing rules and stuff. Knowing a little about D&D, or at the very least about RPG's in general, will be helpful when reading it, even if it's not absolutely compulsory.
There's a caveat, of course. As can be expected of a product of this millennium, it naturally makes use of 3.5 edition D&D.
I don't know what it is exactly that makes me love to hate post-2nd Ed. D&D products. Mostly I guess it's just how it all seems needlessly complicated, with all the skills and feats and prestige classes and whatnot. And there's the increasingly blatant commercial nature of some material, like the yearly release of additional core rulebooks for 4th Edition. I mean, what the hell? Since when are geeks made of money?
I don't own any 3rd or 4th Edition products and don't really know that much about them, so I guess I shouldn't really be too harsh on them. But I do own the 2nd Edition core books, and they hold a special place in my heart as one of the first RPG systems my group actively used. It'd take some really convincing arguments to replace those, which so far I have not seen.